The molecular epidemiology of extended-spectrum beta-lactamase producing organisms.
نویسنده
چکیده
that hospital outbreaks of ESBL-producing E. coli may occur6. The reason why ESBL-producing K. pneumoniae is more likely to cause clusters of infection than E. coli has not been fully explored. While scores of scientists study bacterial pathogenesis, attention must surely be placed by the scientific community on the reasons why some strains are more “hospital-adapted” than others. Ability to attenuate bacterial colonization of hands, inanimate surfaces within the hospital environment and medical devices will be an important step in reducing hospital-acquired infections. The final piece of interesting information to be gained from this study is the spectrum of ESBL types characterized. As has been observed worldwide, the CTX-M type ESBLs are clearly predominant. This now appears to be true within hospitals and in the community3. Some dominant SHV types continue to be important with SHV-12 holding a prominent place in this regard. In contrast, TEM type ESBLs are now almost non-existent in Spanish hospitals. One of the impacts of ESBL-producing organisms is their effect on empiric antibiotic use. Typically, an individual and an institutional response to ESBL-producers is increased use of carbapenems or beta-lactam/beta-lactamase inhibitor combinations. Recent trends around the world have included the advent of KPC and metallo-beta-lacatamses capable of hydrolysing carbapenems and plasmid-mediated AmpC beta-lactamases which are resistant to inhibition by currently available beta-lactamase inhibitors. Looking forward, it would be wise to complement surveillance of the molecular epidemiology of ESBL producing Enterobacteriaceae with surveillance of carbapenem and beta-lactamase inhibitor resistant K. pneumoniae and E. coli as well. Spain is indeed fortunate that collaborative multi-institutional studies such as this are readily performed and published so that such trends can be readily identified.
منابع مشابه
Prevalence and Molecular Characterization of Plasmid-mediated Extended-Spectrum β-Lactamase Genes (balaTEM, blaCTX and blASHV) Among Urinary Escherichia coli Clinical Isolates in Mashhad, Iran
Objective(s) Extended-spectrum beta-lactamase (ESBL) producing bacteria have an important role in nosocomial infections. Due to the limited availability of information about the molecular epidemiology of ESBL producing bacteria in Mashhad, we decided to investigate about TEM, CTX and SHV ESBLs among urinary Escherichia coli isolates in Mashhad, a city in northeast Iran. Materials and Methods ...
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ورودعنوان ژورنال:
- Enfermedades infecciosas y microbiologia clinica
دوره 26 7 شماره
صفحات -
تاریخ انتشار 2008